New chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders.

Citation: 
R.A. Vishwakarma, S.K. Jain, S.B. Bharate, A.H. Dar, A. Khajuria, M. Samdarshi, S.K. Bhola, Qazi AK, A. Hussain, T. Sidiq, R. Uma Shaanker, G. Ravikanth, R. Vasudeva, M.K. Patel, K.N. Ganeshaiah. 2014. New chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders. Patent Number: WO2014167580A1
Authors: 
R.A. Vishwakarma, S.K. Jain, S.B. Bharate, A.H. Dar, A. Khajuria, M. Samdarshi, S.K. Bhola, Qazi AK, A. Hussain, T. Sidiq, R. Uma Shaanker, G. Ravikanth, R. Vasudeva, M.K. Patel, K.N. Ganeshaiah.
Other Details: 
October 16, 2014

(EN) The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant Dysoxylum binectariferum. The compound 5,7-dihydroxy-6-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one, is found to be a potential inhibitor of cell growth and proliferation and also inhibits production of pro-inflammatory cytokines. The formulations of this particular compound can be used for treatment of cancer and inflammation. (FR) La présente invention concerne un nouvel alcaloïde chromone de formule 1 isolé de la plante Dysoxylum binectariferum. Le composé 5,7-dihydroxy-6-(3-hydroxy-1-méthylpipéridin-4-yl)-2-méthyl-4H-chromène-4-one s'est avéré être un inhibiteur potentiel de la croissance et de la prolifération cellulaire et inhibe également la production de cytokines pro-inflammatoires. Les formulations de ce composé particulier peuvent être utilisées pour le traitement du cancer et d'inflammations.

Programme: 
Biodiversity Monitoring and Conservation Planning
Full Text URL: 
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2014167580&tab=PCTBIBLIO&maxRec=1000
Year of publication: 
10.2014
People: 
Dr. Ganeshaiah KN
Dr. G Ravikanth
Dr R Uma Shaanker
Projects: 
Biotechnological Interventions for conservation and utilization of forest resources. Funded by Department of Biotechnology (DBT) New Delhi.
Non-ATREE Publication(Y/N): 
No